set-7 — Neurospora crassa

Summary

NCU07496, designated set-7 in Neurospora crassa, encodes a SET-7 protein that possesses histone H3K27 methylase and trimethylase activities, along with chromatin-binding and metal-binding functions. The product contains EZH2_N, Ezh2_CXC_fung, Ezh2_MCSS, CXC, and SET domains, placing it in the EZH1/2-like family. It is associated with the PRC2 complex and localizes to the nucleus. Biologically, set-7 is associated with chromatin silencing, chromatin remodeling, DNA-dependent transcription, methylation, and ectoderm development. Related genes in other species link the gene family to similar chromatin regulatory roles.