CSH3 — Neurospora crassa

Summary

NcCSH3 (NCU07403) on chromosome 1 of Neurospora crassa encodes the secretory component protein SHR3, a member of the Psh3/Shr3 family. The product is associated with unfolded protein binding and is localized to the ER membrane, where it is linked to ER-to-Golgi transport. The gene has been connected to numerous phenotypes, including increased UV resistance, increased flocculation and biofilm formation, decreased nutrient uptake and protein secretion, abnormal endomembrane and ER morphology, absent cell death and autophagy, and increased sporulation efficiency. It is also associated with normal exponential-phase growth and sporulation. Studies of related genes in other species link the family to nitrogen source utilization and pseudohyphal growth.