BCR1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G26447 (BCR1, also known as C2H079) on chromosome 4 of Fusarium graminearum PH-1 encodes a C2H2 zinc-finger transcription factor of the CreA/MIG family. It has DNA-binding transcription factor activity and is associated with carbon catabolite repression, regulation of carbon utilization, and downregulation of transcription by glucose. The gene is linked to glycogen metabolism, the oxidative pentose pathway, toxin and ergosterol anabolism, chitin metabolism, hyphal growth, asexual reproduction, MAPK cascade signaling, and chromatin remodeling. It localizes to both the cytoplasm and nucleus. Phenotypic associations include absent spindle morphology and chromosome segregation, increased sporulation, arrested G2 phase, absent meiosis and nuclear fusion, abnormal pseudohyphal growth, decreased UV resistance and nitrogen utilization, and altered cell cycle progression. Studies of related genes in other species link the family to sugar content, germination rate, and oxidative stress response.