SRE — Fusarium graminearum PH-1

Summary

FgSRE (FGRAMPH1_01G26781) on chromosome 4 of Fusarium graminearum PH-1 encodes a GATA-family transcription factor with iron sensor activity, 2Fe-2S cluster binding, and DNA-binding transcription repressor activity specific to RNA polymerase II. The gene is associated with cellular iron ion homeostasis, downregulation of ferrichrome anabolism and iron ion transport, siderophore anabolism, cellular responses to iron and copper, deubiquitination, nitric oxide storage, and both positive and negative regulation of transcription by RNA polymerase II. Its product localizes to chromatin, cytoplasm, and nucleus. Studies of related genes in other species link the family to iron concentration, oxidative stress response, and polysaccharide content, as well as to unaffected pathogenicity and reduced virulence.