PST1 — Fusarium graminearum PH-1

Summary

FgPST1 (FGRAMPH1_01G27415) on chromosome 4 of Fusarium graminearum PH-1 encodes a Sin3-like protein containing PAH and HDAC-interacting domains, with transcription corepressor activity and bridging binding function. The gene is associated with chromatin-mediated transcription regulation, centromeric silencing, non-homologous end joining, sexual reproduction, mycotoxin anabolism, cell division, and homeostasis. Its product localises to the nucleus, cytosol, chromatin, centric heterochromatin, and the Clr6-LE complex. Phenotypic associations include increased virulence, altered cell cycle progression, abnormal mating-type switching, delayed exit from stationary phase, increased carbon source utilisation, and premature RNA and protein accumulation. Related genes in other species link it to the Rpd3S and Rpd3C(L) complexes and response to pH.