PEX14 — Fusarium graminearum PH-1

Summary

FgPEX14 (FGRAMPH1_01G27525) on chromosome 4 of Fusarium graminearum PH-1 encodes a peroxin-14 family protein containing a Pex14_N domain and a WH-like DNA-binding superfamily domain. The product is associated with signaling receptor binding and localizes to the peroxisome membrane, where it is associated with peroxisomal matrix protein import and docking. The gene is linked to peroxisome morphology and transport, pexophagy, macroautophagy, vacuolar transport, mycotoxin anabolism, morphogenesis, and proteolysis. Phenotypic associations include abnormal peroxisomal distribution and morphology, absent peroxisomal transport, increased hyperosmotic stress resistance, increased survival rate in stationary phase, increased carbon source utilization, decreased chitin deposition, decreased mating response, delayed meiosis, and abnormal cell cycle progression. Studies of related genes in other species link the family to altered virulence, including hypervirulence and loss of pathogenicity.