NDC80 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G27527 (symbol NDC80, also known as FgNDC80) on chromosome 4 of Fusarium graminearum PH-1 encodes a kinetochore adaptor with microtubule-binding activity, belonging to the Ndc80 protein family. The product localizes to the outer kinetochore, Ndc80 complex, centromere and nucleus, and is associated with microtubule nucleation and dynamics, meiotic centromere clustering, spindle attachment during both mitosis and meiosis, sister chromatid biorientation, and cell division. The gene is linked to both asexual and sexual reproduction. Phenotypic associations include abnormal cell cycle progression through metaphase-anaphase, delayed or arrested anaphase, premature meiosis, delayed sporulation, abnormal pseudohyphal growth, decreased mitotic recombination, increased nucleus size, and altered chronological lifespan. Related genes in other species are linked to kinetochore assembly and chromosome segregation.