ENA1 — Fusarium graminearum PH-1

Summary

FgENA1 (FGRAMPH1_01G28193) on chromosome 4 of Fusarium graminearum PH-1 encodes a P-type ATPase of the IID subfamily with potassium:proton transporter, sodium transporter, manganese transporter and calcium transporter activities, as well as ATP hydrolase activity and calcium ion binding. The gene is associated with potassium and sodium ion export from the cell, cellular pH regulation, calcium and manganese ion membrane transport, and responses to unfolded proteins. It localises to the plasma membrane, lipid rafts, vacuolar membrane, Golgi membrane and nuclear envelope. Phenotypic associations link FgENA1 to cell cycle progression, endocytosis, vacuolar transport, desiccation resistance, freeze-thaw resistance, necrotic cell death, chitin deposition, respiratory metabolism, and starvation resistance. Studies of related genes in other species connect the family to sodium concentration, potassium content, and virulence.