HRP1 — Fusarium graminearum PH-1

Summary

FgHRP1 (FGRAMPH1_01G30320) on chromosome 1 of Fusarium graminearum PH-1 encodes an RNA-binding protein with poly(A)-, poly(U)- and mRNA 3′-UTR-binding activity, containing RRM and Hrp1_RRM1 domains. The gene is associated with cotranscriptional 3′ processing of RNA polymerase II transcripts, mRNA processing, transport and nuclear export, regulation of translation and gene expression, sexual reproduction, hyphal growth, and methylation. Its product localises to the nucleus, cytosol, stress granules, the perinuclear region and the mRNA cleavage stimulating factor complex. Phenotypic associations link FgHRP1 to abnormal protein activity and prion inheritance, increased nutrient uptake and gamma ray resistance, delayed vegetative growth and cell cycle progression, decreased colony size, altered carbon source utilisation, and absent innate thermotolerance and adhesion. Related genes in other species are associated with lethal phenotypes and pathogenicity.