GCN5 — Fusarium graminearum PH-1

Summary

FgGCN5 (FGRAMPH1_01G00753) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with GNAT and bromodomain families, possessing histone H3K9, H3K14, H3K18 acetyltransferase activity, histone crotonyltransferase activity, and histone H4K16ac, H4K12ac, H3K56ac reader activity, acting as a transcription coactivator and chromatin adaptor. It is associated with perithecium formation, sexual reproduction, sporulation, mycotoxin and pigment anabolism, secondary metabolism, regulation of autophagy, DNA repair-dependent chromatin remodeling, homologous recombination, and deubiquitination. Localized to the nucleus, cytoplasm, chromatin, centromere complex, and histone acetylase complexes including ADA and SALSA complexes. Phenotypic associations include increased sporulation rate, abnormal mitophagy, increased transposable element transposition, altered cell cycle progression, and increased carbon source utilization. Related genes in other species link the family to SAGA complex localization and altered virulence.