ATB2 — Fusarium graminearum PH-1

Summary

FgATB2 (ATB2) on chromosome 1 of Fusarium graminearum PH-1 encodes an alpha tubulin protein, a structural constituent of the cytoskeleton with GTP-binding and hydrolase activity. The gene is associated with microtubule-based processes, including microtubule cytoskeleton organization and assembly, as well as nuclear migration, division, and the mitotic and meiotic cell cycles. It is linked to both asexual and sexual reproduction, specifically perithecium formation, ascospore formation, and hyphal growth. Phenotypic associations include abnormal colony size, spore germination, and spindle morphology, along with altered cell cycle progression, particularly in anaphase, and effects on chromosome segregation and nuclear size. The gene product localizes to microtubules, the spindle, and the tubulin complex.