PRP4 — Fusarium graminearum PH-1

Summary

FgPRP4 (FGRAMPH1_01G01203) on chromosome 1 of Fusarium graminearum PH-1 encodes a PRP4-like protein containing WD40 repeats. The product exhibits U4 and U6 snRNA binding, histone binding, GTP binding, transcription corepressor activity, and general transcription factor II activity. It is associated with mRNA splicing via the spliceosome, mRNA processing, transcription initiation from RNA polymerase II promoters, chromatin-mediated transcription maintenance, telomeric silencing, and both upregulation and downregulation of DNA-dependent transcription. The protein localizes to the U4/U6.U5 snRNP complex, SAGA complex, Set1C, TFIID complex, Tup11/Tup12 repressor complex, histone methyltransferase complex, chromatin, and telomeric regions. Associations include abnormal colony shape, cytokinesis, and spindle morphology; increased pheromone sensitivity and mating response; altered fermentative and respiratory metabolism; increased lifespan and pseudohyphal growth; decreased protein transport, X-ray resistance, and alkaline pH resistance; increased telomere length; and delayed G1/S phase transition.