SLP1 — Fusarium graminearum PH-1

Summary

FgSLP1 (FGRAMPH1_01G01663) on chromosome 1 of Fusarium graminearum PH-1 encodes a Cdc20/Fizzy family protein with WD40 repeats and is annotated with ubiquitin ligase activator activity, APC binding, transcription corepressor activity, histone binding, and GTP binding. The gene is associated with cell cycle regulation, particularly the metaphase/anaphase transitions during both meiosis I and meiosis II, as well as positive regulation of anaphase-promoting complex-dependent catabolic process, positive regulation of ascospore formation, positive regulation of meiotic cell cycle, and negative regulation of G1/S transition of mitotic cell cycle. FgSLP1 has been linked to spore formation, cell death, signal transduction, and negative regulation of transcription by RNA polymerase II. Phenotypic associations include altered cell cycle progression through anaphase and G2 phase, premature or arrested meiosis, abnormal chromosome segregation, and increased sporulation. The protein localizes to the cyclosome, kinetochore, mitotic spindle, spindle pole body, chromatin, and the Tup11/Tup12 repressor complex. Studies of related genes in other species link the family to mitotic checkpoint control.