NAG6 — Fusarium graminearum PH-1

Summary

FgNAG6 (NAG6, SEY1) on chromosome 1 of Fusarium graminearum PH-1 encodes a GTPase with GTP-binding activity, belonging to the Sey1/RHD3-like 3HB and RHD3/Sey1 protein families. The gene is associated with ER membrane fusion, ER inheritance, and localisation to the cortical ER and ER membrane. Phenotypic associations include absent spore germination, increased cell death, decreased meiosis, abnormal chromosome segregation, increased polyploidy, and altered autophagy, mitophagy, reticulophagy, and nucleophagy. The gene is also linked to abnormal endomembrane system and spindle morphology, decreased protein secretion and transport, and abnormal nuclear export. Studies of related genes in other species connect the family to decreased nuclear fusion during mating and abnormal colony appearance, and to reduced virulence and fusarium head blight.