SSA1 — Fusarium graminearum PH-1

Summary

FgSSA1 (SSA1) on chromosome 1 of Fusarium graminearum PH-1 encodes a member of the Hsp70 family of molecular chaperones, possessing ATP hydrolase activity, ATP binding, peptide binding, heat shock protein binding, and protein folding chaperone functions, and also acts as a transcriptional co-regulator. The gene is associated with protein folding and refolding, peptide transport, vacuole fusion, endocytosis, autophagy, dephosphorylation, cellular osmotic response, response to toxic substances, cellular response to farnesol, and DNA-dependent transcription. Its product localizes to the cytoplasm, cytosol, nucleus, membrane, plasmalemma, hyphal and fungal-type cell walls, fungal biofilm matrix, and extracellular. Phenotypic associations include increased thermotolerance, altered cell cycle progression, abnormal spore germination, premature apoptosis, increased prion inheritance, and increased nutrient uptake. Related genes in other species link the family to oxidative stress response and acid sensitivity.