RRD2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G02727 (RRD2, also known as YPA2 or FgYPA2) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with protein tyrosine phosphatase activator activity and cis-trans proline isomerase activity, belonging to the PTPA superfamily and containing a PTPA_C_lid domain. The gene is associated with the PP2A complex and localizes to the cytoplasm and nucleus. It is associated with regulation of the septation initiation network, TOR signaling, mitotic spindle organization, osmotic response, mycotoxin anabolism, methylation, and cell growth. Phenotypic associations include increased virulence, decreased polyploidy, abnormal aneuploidy, altered fermentative and respiratory metabolism, increased hydrostatic pressure resistance, decreased chitin deposition, absent cytokinesis, increased mating response, and arrested exponential-phase growth. Studies of related genes in other species connect the family to peptidyl-prolyl cis-trans isomerase activity (EC 5.2.1.8).