PRP31 — Fusarium graminearum PH-1

Summary

FgPRP31 (FGRAMPH1_01G03217) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with a Prp31_C domain and a Nop domain, and is annotated for snRNA, snoRNA and RNA binding. The gene is associated with spliceosomal tri-snRNP assembly, mRNA splicing via the spliceosome, and rRNA processing, including endonucleolytic cleavage steps and snoRNA-guided 2'-O-methylation. Its product localises to the nucleolus, nucleus, U4 snRNP, U4/U6.U5 snRNP complex, box C/D methylation guide snoRNP complex, SSU processome and precatalytic spliceosome. Associations with phenotypes include temperature-sensitive growth, increased pheromone sensitivity and mating response, abnormal cell cycle progression, increased flocculation, decreased X-ray resistance, increased lifespan, and abnormal budding and cell size. Related genes in other species are linked to abnormal cell cycle progression and mitochondrial morphology.