FMA1 — Fusarium graminearum PH-1

Summary

FgFMA1 (FGRAMPH1_01G03433) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with initiator methionyl aminopeptidase activity, metalloaminopeptidase activity, and zinc binding, belonging to the Pept_M24 family and containing a Zfn-C6H2 domain. The gene is associated with appressorium formation and protein processing, and its product localizes to the nucleolus and cytosol. Phenotypic associations include decreased cell cycle progression in G2 phase, telophase arrest, decreased exponential growth, abnormal nuclear position and spindle morphology, increased lifespan, decreased freeze-thaw and ionic stress resistance, increased nucleolus size, abnormal colony appearance and actin cytoskeleton, decreased sporulation and fermentative growth, increased cell size and thermotolerance, and altered carbon source utilization. Related genes in other species are linked to oxidative stress response and decreased colony size.