VPS29 — Fusarium graminearum PH-1

Summary

FgVPS29 (FGRAMPH1_01G03785) on chromosome 1 encodes a protein with a phosphodiesterase MJ0936/Vps29 domain. The gene is associated with vesicle formation, retrograde transport from endosome to Golgi, intracellular protein transport, and vacuolar protein sorting. It localises to endosomes, cytosol, and nucleus. FgVPS29 is linked to ascospore formation, abnormal meiosis, and decreased spore germination rate. It is associated with absent endocytosis, autophagy, mitophagy, and pexophagy, as well as increased ionic stress and desiccation resistance, abnormal vacuolar transport, and altered cell cycle progression. Related genes in other species link the family to the retromer complex and reduced virulence.