CAP1 — Fusarium graminearum PH-1

Summary

FgCAP1 (CAP1) on chromosome 1 of Fusarium graminearum PH-1 encodes an adenylyl cyclase-associated protein (CAP) with CAP_N and CAP_C domains, and is annotated for adenylyl cyclase binding, actin binding, and identical protein binding. The gene is associated with actin filament destabilization, depolymerization, and severing, as well as regulation of actin polymerization and organization. It is linked to Ras protein signal transduction, the glucose-sensing PKA pathway, hyphal growth, sexual reproduction, endocytosis, and positive regulation of mitochondrial fission. Localization evidence connects the product to the growing cell tip, division septum, cross wall, actin patch, and cytoplasm. Phenotypic associations include abnormal filamentous growth, absent spore germination, sterility, abnormal endocytosis, altered pheromone sensitivity and production, and increased G1 cell cycle progression. Related genes in other species link the family to reduced virulence and oxidative stress response.