SOD2 — Fusarium graminearum PH-1

Summary

FgSOD2 (FGRAMPH1_01G04949) on chromosome 1 of Fusarium graminearum PH-1 encodes a superoxide dismutase with Mn/Fe-binding domains, possessing superoxide dismutase activity and manganese binding. It is associated with evasion or tolerance of host-produced AOS and removal of O₂⁻. The protein localises to mitochondria, the mitochondrial lumen, and the cytosol. FgSOD2 is linked to numerous phenotypes, including increased necrotic cell death, abnormal septum and spore wall formation, altered respiratory and fermentative metabolism, increased freeze-thaw and hydrostatic pressure resistance, decreased radiation and pheromone sensitivity, and changes in cell cycle progression and stationary phase entry. It is also connected to photosynthetic rate. Studies of related superoxide dismutase family members in other species link the family to oxidative stress response, sodium concentration, and manganese content.