FIP1 — Fusarium graminearum PH-1

Summary

FgFIP1 (FGRAMPH1_01G05161) on chromosome 1 of Fusarium graminearum PH-1 encodes a member of the FTR1/Fip1/EfeU family and has high-affinity ferrous iron transmembrane transporter activity. The gene is associated with reductive iron assimilation, cellular response to iron ion starvation, and regulation of gene expression, and its product localises to the high-affinity iron permease complex, Golgi complex, and plasmalemma. FgFIP1 is linked to numerous phenotypes including decreased filamentous growth, sporulation efficiency, and fermentative growth, as well as increased stress resistance, metal resistance, and innate thermotolerance. It is also connected to altered cell shape, budding pattern, and increased cold sensitivity. Studies of related genes in other species link the family to reduced virulence and invasive growth.