NRPS4 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G05575 (NRPS4) on chromosome 1 of Fusarium graminearum PH-1 encodes a non-ribosomal peptide synthetase, possessing domains including an adenylation domain, condensation domain, and phosphopantetheine attachment site, and is annotated with non-ribosomal peptide synthetase activity, CoA-ligase activity, and phosphopantetheine binding. The gene is associated with amino acid activation for nonribosomal peptide biosynthetic process, secondary metabolism, and methylation, and its product localizes to the cytoplasm. Studies of related genes in other species link the NRPS4 family to reduced virulence and invasive pulmonary aspergillosis in Galleria mellonella models.