ERG-3 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G05637 (symbol ERG-3, preferred name ERG24B) in Fusarium graminearum PH-1 encodes a protein with a sterol reductase domain and D14-sterol reductase activity and NADP binding, localised to the endoplasmic reticulum membrane. The gene is associated with ergosterol biosynthesis, pyrophosphate metabolism, membrane transport, filamentous growth in response to biotic stimuli, and cellular response to xenobiotic stimuli. Phenotypic associations include abnormal plasma membrane morphology, vacuolar transport defects, decreased spore germination, altered vegetative growth, increased cell death, impaired mating response, reduced nutrient uptake and utilisation, abnormal autophagy, and absent micronucleophagy. Related genes in other species link the family to salt tolerance, phosphate content, acid sensitivity, and oxidative stress response.