UBP14 — Fusarium graminearum PH-1

Summary

FgUBP14 (UBP14) on chromosome 1 of Fusarium graminearum PH-1 encodes a ubiquitinyl hydrolase with domains including UBP13_Znf-UBP_var, Znf_UBP, Peptidase_C19, USP, and UBA. The product possesses K48-linked and metal-dependent deubiquitinase activity, thiol-dependent deubiquitinase activity, transcription coactivator activity, and zinc binding. It is associated with deubiquitination, regulation of protein stability, proteasomal pathway, proteolysis, autophagy, chromatin-mediated maintenance of transcription, and regulation of transcription by RNA polymerase II. The protein localizes to the DUBm and SAGA complexes, nucleoplasm, cytosol, and nucleus. Phenotypic associations include increased sporulation rate, decreased colony sectoring, increased adhesion, abnormal fermentative metabolism, decreased ribophagy and pexophagy, decreased prion inheritance, and decreased radiation resistance. Sequence similarity links the family to loss of pathogenicity and fusarium head blight in other species.