RPB2 — Fusarium graminearum PH-1

Summary

FgRPB2 (RPB2) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with DNA-directed RNA polymerase activity, RNA-dependent RNA polymerase activity, and binds ribonucleosides, RNA, DNA, and zinc. It is associated with transcription initiation, elongation, and termination from RNA polymerase I, II, and III promoters, as well as snRNA transcription by RNA polymerase III, RNA-templated transcription, RNAi-mediated heterochromatin assembly at centromeres, mating, and translation elongation. The protein localises to the nucleus, cytosol, chromatin, centric heterochromatin, and the RNA polymerase I, II, and III complexes. Phenotypic associations link the gene to abnormal fermentative and respiratory metabolism, decreased sulfur utilisation, increased aneuploidy, delayed meiosis, decreased meiotic recombination, increased G2 and S phase duration, absent silencing and endocytosis, and altered spore wall formation.