SSP2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G06787 (SSP2, also known as Snf1, FgSSP2, FgPRK-10, or PRK-10) in Fusarium graminearum PH-1 encodes a serine/threonine protein kinase with protein kinase A activity, belonging to the SNF1-related kinase family. The gene is associated with energy homeostasis, the CAMKK-AMPK signaling cascade, and responses to glucose, including regulation of invasive growth under glucose limitation and upregulation of gluconeogenesis. It is linked to positive and negative regulation of pseudohyphal growth, negative regulation of translation and inositol phosphate biosynthesis, mycose catabolism, fungal-type cell wall assembly, and septin ring assembly. The encoded protein localizes to the nucleotide-activated protein kinase complex, cellular bud neck, septin ring, nuclear membrane, and vacuolar membrane. Studies of related genes in other species link the family to turgor pressure, reduced virulence, and loss of pathogenicity.