CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G06829) on chromosome 1 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme binding and iron binding activity, classified as an oxidoreductase acting on paired donors with incorporation of molecular oxygen. The gene is associated with ergosterol, terpenoid, and mycotoxin anabolism. It has been linked to numerous cellular processes including decreased colony size, vegetative growth arrest, increased cell death, abnormal plasma membrane and cytoskeleton morphology, defective vacuolar transport, absent micronucleophagy, decreased meiosis and mating response, increased budding, and altered cell cycle progression through the G2/M phase transition. Additional associations include abnormal telomere length, mitochondrial distribution and genome maintenance, decreased nutrient uptake, and altered endocytosis and autophagy. The gene also shows connections to increased fermentative growth rate, absent protein secretion, and increased small molecule transport.