BOI1 — Fusarium graminearum PH-1

Summary

FgBOI1 (FGRAMPH1_01G07083) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein containing pleckstrin homology (PH), SAM, and SH3 domains, and is annotated with lipid binding molecular function. The gene is associated with receptor recycling, endosome organization, retrograde transport from endosome to Golgi, exocytosis, and cytokinesis. Its product localizes to recycling and early endosomes, the trans-Golgi network, the medial ring, cell cortex, cell tip, cell division site, membrane, and cytosol. FgBOI1 is linked to numerous phenotypes including absent bipolar budding, decreased redox state, increased thermotolerance, arrested cell cycle progression at anaphase and telophase, absent chromosome segregation, increased mating efficiency, abnormal filamentous growth, decreased necrotic cell death, and altered responses to oxidative and hyperosmotic stress. Studies of related genes in other species connect the family to polarized growth and Cdc42 signaling.