CP1 — Fusarium graminearum PH-1

Summary

FgCP1 (FGRAMPH1_01G07391) on chromosome 1 of Fusarium graminearum PH-1 encodes a serine carboxypeptidase belonging to the peptidase S10 family, with an alpha/beta hydrolase fold. The gene is associated with proteolysis, vacuolar protein sorting, Golgi-to-vacuole transport, and localization to the trans-Golgi network. It has been linked to sexual reproduction, apoptotic processes, secondary metabolism, and methylation. Phenotypic associations include abnormal nuclear fusion during mating, altered cell death (both increased and decreased), abnormal autophagy, mitophagy, pexophagy, and ribophagy, as well as effects on protein secretion, endocytosis, cytokinesis, prion inheritance, aneuploidy, and lifespan. Related genes in other species connect it to serine carboxypeptidase activity (EC 3.4.16.6) and apoplastic effector functions, with distant sequence similarity to genes involved in floral organ identity.