ISW1 — Fusarium graminearum PH-1

Summary

FgISW1 (FGRAMPH1_01G07691) on chromosome 1 of Fusarium graminearum PH-1 encodes a protein with domains including Isw1/2_DEXHc, ISWI_HAND-dom, SLIDE, SANT_dom, SNF2/RAD54-like_C, SNF2_N, Helicase_ATP-bd, and Helicase_C. It is annotated with ATP-dependent chromatin remodeler activity, histone octamer slider activity, nucleosome array spacer activity, DNA translocase activity, helicase activity, and histone/nucleosome/chromatin binding activities. It is associated with numerous chromatin-related processes including nucleosome organization and disassembly, heterochromatin boundary formation, transposable element silencing, tRNA transcription, regulation of TOR signaling, DNA double-strand break processing, and chlamydospore formation. The gene is linked to the SHREC, CHRAC, INO80, and SWI-SNF complexes, and localizes to heterochromatin islands and CENP-A-containing chromatin. Phenotypic associations include abnormal cell cycle progression, altered mutation frequency, decreased adhesion, and effects on meiosis and mating. Studies of related genes in other species link the family to pathogenicity and virulence.