DSPC — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G08303 (DSPC, also known as YVH1) on chromosome 1 of Fusarium graminearum PH-1 encodes a dual-specificity phosphatase of the DUSP12 family, possessing protein tyrosine/serine/threonine phosphatase activity. The gene is associated with cytosolic large ribosomal subunit assembly and signaling, and its product localizes to both the cytosol and nucleus. DSPC is associated with delayed sporulation, cell cycle progression, and endocytosis, as well as altered vegetative growth, increased resistance to ionic and hyperosmotic stress, and abnormal spore wall formation. Additional associations include decreased nuclear import, absent pexophagy, and increased desiccation resistance. Studies of related genes in other species connect the family to meiosis and acid pH resistance.