LEU2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G08667 (LEU2) on chromosome 1 of Fusarium graminearum PH-1 encodes a 3-isopropylmalate dehydrogenase, an enzyme with 3-isopropylmalate dehydrogenase activity that requires NAD and magnesium. The gene is associated with pigmentation, L-leucine anabolism, the glyoxylate cycle, and morphogenesis, and its product localises to the cytosol. Studies of related genes in other species link the family to leucine metabolism and fungal development, though these associations are not yet established for this specific gene.