CI-1 — Fusarium graminearum PH-1

Summary

FgCI-1 (FGRAMPH1_01G08895) on chromosome 2 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase with heme binding, iron binding, and oxidoreductase activity. This membrane-associated ER protein is linked to the biosynthesis of ergosterol, griseofulvin, mycophenolic acid, cichorine, terpenoids, and other secondary metabolites. The gene is associated with numerous cellular and developmental phenotypes, including decreased colony size, vegetative growth arrest, increased cell death, abnormal cytoskeleton and plasma membrane morphology, defective endocytosis, vacuolar transport, micronucleophagy, autophagy, meiosis, cytokinesis, and shmoo formation, as well as altered cell cycle progression, budding, fermentative growth, and nutrient uptake. Related genes in other species are linked to potassium concentration and acid sensitivity traits.