CP1 — Fusarium graminearum PH-1

Summary

FgCP1 (FGRAMPH1_01G09999) on chromosome 2 of Fusarium graminearum PH-1 encodes a serine carboxypeptidase belonging to the peptidase S10 family with an AB hydrolase domain. The gene is associated with proteolysis, vacuolar protein sorting, Golgi-to-vacuole transport, sexual reproduction, secondary metabolism, and methylation. Its product localizes to the fungal-type vacuole, plasmalemma, extracellular region, and side of membrane. Phenotypic associations include abnormal nuclear fusion during mating, altered cell death, increased acquired thermotolerance, increased aneuploidy, abnormal autophagy, absent mitophagy and pexophagy, delayed endocytosis, abnormal Golgi morphology, and increased lifespan. The gene is also linked to altered prion inheritance, decreased cytokinesis, abnormal protein secretion, and changes in chemical compound and protein/peptide accumulation. Related genes in other species connect the family to apoplastic effector functions and floral organ identity.