CDC2 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G10041 (CDC2) on chromosome 2 of Fusarium graminearum PH-1 encodes a cyclin-dependent protein kinase with serine/threonine kinase activity, capable of binding cyclins, histones, RNA polymerase II core, and ATP. The protein belongs to the CDK and protein kinase domain families. This gene is associated with the regulation of cell cycle processes, including mitotic and meiotic DNA replication, spindle dynamics, and chromosome segregation, as well as responses to DNA damage checkpoints and glucose starvation. It is also linked to the positive regulation of glycogenolysis, triglyceride catabolism, and protein breakdown, and to negative regulation of primary cell septum biogenesis and anaphase-promoting complex activity. The product localizes to CDK-cyclin complexes, meiotic and mitotic spindles, spindle pole bodies, and telomeric regions. Studies of related genes in other species link the family to virulence and pathogenicity.