FUM1 — Fusarium graminearum PH-1

Summary

FgFUM1 (FGRAMPH1_01G10639) on chromosome 2 of Fusarium graminearum PH-1 encodes a fumarate hydratase, an enzyme with fumarate hydratase activity. The protein contains fumarase and is localized to mitochondria, the mitochondrial lumen, cytosol, and nucleus. This gene is associated with fumarate and malate metabolism, the TCA cycle, asexual and sexual reproduction, fumonisin and mycotoxin anabolism, sphingolipid anabolism, double-strand break repair, and the DNA damage response. Studies of related genes in other species link the family to seedling rot and unaffected pathogenicity in hosts such as Medicago sativa, Verticillium dahliae, and Fusarium oxysporum, though these associations are not established for FgFUM1 itself.