CPP1 — Fusarium graminearum PH-1

Summary

FgCPP1 (CPP1, RAM1) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with protein farnesyltransferase activity, GGTaseI activity, GGTaseII activity, small GTPase binding, and metal binding, belonging to the PGGT1B-like and terpenoid cyclase/prenyltransferase families. It is associated with protein farnesylation, protein geranylgeranylation, establishment of protein localization to the plasma membrane, ER-to-Golgi transport, and cell physiology. The gene product localizes to the cytoplasm, nucleus, and farnesyltransferase and geranylgeranyltransferase complexes. Phenotypic associations include absent or decreased mating efficiency and pheromone production, decreased pheromone sensitivity, abnormal cell wall morphology and spore wall formation, decreased chitin deposition, increased pseudohyphal growth, decreased apoptosis, increased lifespan, and decreased acquired thermotolerance. Studies of related genes in other species link the family to reduced virulence and absent sporulation.