GDT1 — Fusarium graminearum PH-1

Summary

FgGDT1 (FGRAMPH1_01G11057) on chromosome 2 of Fusarium graminearum PH-1 encodes a GDT1-like protein with manganese:proton antiporter, calcium:proton antiporter, and calcium and manganese ion transmembrane transporter activities. The gene is associated with Golgi calcium ion transport and homeostasis, manganese ion membrane transport, and proton transmembrane transport, and its product localises to the Golgi complex, endoplasmic reticulum membrane, and ER. FgGDT1 is associated with abnormal Golgi and ER morphology, decreased mating efficiency and pheromone production, altered autophagy and mitophagy, increased apoptosis, increased vegetative and respiratory growth, decreased freeze-thaw and alkaline pH resistance, altered cell cycle progression, and changes in protein transport and modification. Studies of related GDT1/UPF0016 family members in other species connect the family to calcium sensitivity.