CAF5 — Fusarium graminearum PH-1

Summary

FgCAF5 (FGRAMPH1_01G11495) on chromosome 2 of Fusarium graminearum PH-1 encodes a major facilitator superfamily (MFS) transporter with fluconazole, xenobiotic, and spermine transmembrane transporter activity. The gene is associated with transport of fluconazole, spermidine, and spermine, as well as responses to antibiotics, xenobiotic stimuli, and oxidative stress. Its product localises to the plasma membrane, endoplasmic reticulum, and Golgi complex. FgCAF5 has been linked to numerous phenotypes including decreased cell cycle progression in S phase, increased survival in stationary phase, increased filamentous growth, decreased sporulation efficiency, increased stress resistance, decreased UV resistance, and abnormal cell shape and budding pattern. Related genes in other species are associated with reduced virulence and oxidative stress response.