HOG1 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G12171 (HOG1) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with serine/threonine protein kinase activity and ERK1-type kinase domains, belonging to the CLK kinase family. The gene is associated with the stress-activated MAPK cascade, osmotic response, and regulation of mRNA processing, RNA splicing, and spliceosomal complex assembly. It is linked to sexual reproduction, conidia formation, mycotoxin anabolism, secondary metabolism, and digestion. Localization evidence connects HOG1 to the nucleus, cytoplasm, mitochondria, cytoskeleton, mitotic actomyosin contractile ring, and cell division site. Studies of related genes in other species link the family to non-specific serine/threonine protein kinase activity and, through sequence similarity, to fusarium ear blight and unaffected pathogenicity.