CHS1 — Fusarium graminearum PH-1

Summary

FgCHS1 (FGRAMPH1_01G12837) on chromosome 2 of Fusarium graminearum PH-1 encodes a chitin synthase with chitin synthase activity, containing chitin synthase domains. It is associated with cell wall biogenesis and organization, chitin anabolism, hyphal growth, conidia formation, homologous recombination, signal transduction, and response to dsRNA. The protein localizes to the plasma membrane, hyphal tip, porous cell septum, and cross wall. Phenotypic associations include absent septum formation, abnormal bipolar budding, decreased flocculation and adhesion, altered cell cycle progression (including G2 phase duration and late anaphase arrest), abnormal chitin deposition, and increased respiratory metabolism. Studies of related genes in other species link the family to reduced virulence, lethal phenotypes, and associations with fusarium head blight and infection.