Tri4 — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G13107 (Tri4) on chromosome 2 of Fusarium graminearum PH-1 encodes a cytochrome P450 monooxygenase, a heme- and iron-binding oxidoreductase that acts on paired donors with incorporation of molecular oxygen. The gene is associated with mycotoxin biosynthesis, including ochratoxin A, aflatoxin and conidiogenone anabolism, as well as with response to mycotoxin, pigmentation, ergosterol biosynthesis, secondary metabolism, carbon catabolite repression, secretion, proteolysis, deubiquitination, actin polymerization, translation elongation and innate immunity. The encoded protein is localised to the membrane. Tri4 has been linked to mycotoxin content, glucose content and phosphate content. Studies of related genes in other species connect the cytochrome P450 family to oxidoreductase activity.