ABCA — Fusarium graminearum PH-1

Summary

FgABCA (FGRAMPH1_01G13579) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC transporter of the PDR/CDR subfamily with ATP hydrolase activity and azole ABC transporter activity. The protein is localised to the plasma membrane and is associated with xenobiotic detoxification via transmembrane export, toxin anabolism, hypersensitivity, DNA repair, seed germination, and extracellular transport. FgABCA has been linked to increased sporulation, decreased cell death, abnormal replicative and chronological lifespan, delayed mitophagy, and aberrant cell cycle progression, pseudohyphal growth, and shmoo formation. Studies of related genes in other species connect the family to reduced virulence and unaffected pathogenicity, as well as to plant traits including leaf number, plant height, root length, drought tolerance, and protein and phosphate content.