LIP1 — Fusarium graminearum PH-1

Summary

FgLIP1 (FGRAMPH1_01G13847) on chromosome 2 of Fusarium graminearum PH-1 encodes a secreted lipase belonging to the Lipase_secreted and AB_hydrolase domain families, with lipase activity. The gene is associated with sexual reproduction, lipolysis, filamentous growth in response to starvation and biotic stimuli, and cellular response to starvation. It is also linked to the TRI8 protein involved in T-2 toxin biosynthesis and to LIP2, which is connected to IL-17. Sequence similarity with related genes in other species links the family to reduced virulence and fusarium head blight, though these associations are not established for FgLIP1 itself. The protein is predicted to localise extracellularly.