LAC1 — Fusarium graminearum PH-1

Summary

FgLAC1 (FGRAMPH1_01G13861) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein with a Lag1/Lac1-like domain and TLC domain, localised to the ER membrane. The gene is associated with ceramide synthase activity, ceramide and sphingolipid anabolism, hyphal growth, and the meiotic cell cycle. It is also linked to the FUM18, FUM17, and ALT7 proteins. Related genes in other species connect the family to sphingosine N-acyltransferase and longevity-assurance functions, with sequence similarity to proteins in Verticillium dahliae and Fusarium oxysporum pathovars.