FMAG — Fusarium graminearum PH-1

Summary

FGRAMPH1_01G14465 (FMAG, also known as Cyp51A) encodes a sterol 14-demethylase, a cytochrome P450 enzyme with heme binding, iron binding, and redox activity, and is associated with methyltransferase activity. This gene is linked to ergosterol and mycotoxin biosynthesis, demethylation, methylation, conidium germination, conidia formation, sporulation, and sexual reproduction. It is localized to the endoplasmic reticulum membrane. Associations with numerous phenotypes include decreased micronucleophagy and ribophagy; abnormal plasma membrane morphology, cell cycle progression, and cytokinesis; increased cell death; arrested vegetative and exponential growth; and decreased invasive growth, hyperosmotic stress resistance, and nutrient uptake. Studies of related genes in other species link the family to virulence and pathogenicity, including fusarium head blight.