AIF1 — Fusarium graminearum PH-1

Summary

FgAIF1 (FGRAMPH1_01G15039) on chromosome 2 of Fusarium graminearum PH-1 encodes a protein containing a FAD/NAD-binding domain and is annotated with electron-transferring-flavoprotein dehydrogenase activity and FAD or FADH2 binding. The gene is associated with negative regulation of ferroptosis, apoptotic mitochondrial changes, upregulation of apoptosis, mitochondrion distribution, mitochondrial fission, macroautophagy, mitophagy, homologous recombination, morphogenesis, proteolysis, autophagy, and homeostasis. Its product localises to the mitochondrial membrane, mitochondrial outer membrane, mitochondria, membrane, cytoplasm, and nucleus. Related genes in other species link the family to oxidoreductase activity, but these associations are not established for FgAIF1 itself.