ABC2 — Fusarium graminearum PH-1

Summary

FgABC2 (ABC2) on chromosome 2 of Fusarium graminearum PH-1 encodes an ABC transporter with ATP hydrolase activity, heme binding, and transmembrane transporter activities for cadmium ions, heme, phytochelatins, and xenobiotics. The protein localizes to the vacuolar membrane, Golgi, plasma membrane, and extracellular vesicles. FgABC2 is associated with heme export from the vacuole, cellular detoxification of cadmium ions, glutathione and PC2 import into vacuoles, xenobiotic detoxification, response to toxic substances and metals, sterol and cichorine anabolism, homotypic vacuole fusion, filamentous growth in response to starvation and biotic stimuli, secretion, and host interaction. Phenotypic associations include altered vacuolar morphology and distribution, decreased endocytosis, abnormal cell cycle progression, increased pexophagy, and changes in stress resistance, protein accumulation, and colony color.