CP1 — Fusarium graminearum PH-1

Summary

FgCP1 (CP1) on chromosome 2 of Fusarium graminearum PH-1 encodes a serine carboxypeptidase belonging to the peptidase S10 and alpha/beta hydrolase families. The gene is associated with proteolysis, zymogen activation, vacuolar protein sorting, Golgi-to-vacuole transport, sexual reproduction, secondary metabolism, and monocarboxylic acid and antibiotic anabolism. The product localises to the fungal-type vacuole lumen, the plasma membrane, and the side of membrane. Phenotypic associations link FgCP1 to abnormal nuclear fusion during mating, altered cell death (both increased and decreased), abnormal autophagy, mitophagy, pexophagy, ribophagy, endocytosis, cytokinesis, protein secretion, Golgi morphology, prion inheritance, aneuploidy, and increased lifespan. Related genes in other species link the family to carboxypeptidase activity (EC 3.4.16.5/6) and apoplastic effector function.